Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies.
نویسندگان
چکیده
Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.
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عنوان ژورنال:
- Journal of medicinal chemistry
دوره 57 13 شماره
صفحات -
تاریخ انتشار 2014